Lications for Crohn’s disease. Gut. 2000;47:39703.n3 PUFAs minimize Th17-cell polarization44. Steinhart AH, Hiruki T, Brzezinski A, Baker JP. Therapy of left-sided ulcerative colitis with butyrate enemas: a controlled trial. Aliment Pharmacol Ther. 1996;ten:7296. 45. Tedelind S, Westberg F, Kjerrulf M, Vidal A. Anti-inflammatory properties in the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. Globe J Gastroenterol. 2007;13:28262. 46. Cavaglieri CR, Nishiyama A, Fernandes LC, Curi R, Miles EA, Calder Pc. Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes. Life Sci. 2003;73:16830. 47. Monk JM, Kim W, Callaway E, Turk HF, Foreman JE, Peters JM, He W, Weeks B, Alaniz RC, McMurray DN, et al. Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARdelta in inflammation-induced colon carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2012;302:G1537. 48. Report of your American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies. J Nutr. 1977;107:1340. 49. NRC. Subcommittee on Laboratory Animal Nutrition. Nutrient needs of laboratory animals. 4th rev. ed. Washington: National Academy of Sciences; 1995. 50. Turk HF, Monk JM, Fan YY, Callaway ES, Weeks B, Chapkin RS. Inhibitory effects of omega-3 fatty acids on injury induced epidermal growth element transactivation contribute to delayed wound healing. Am J Physiol Cell Physiol. 2013;304:C9057. 51. Fan YY, Monk JM, Hou TY, Callway E, Vincent L, Weeks B, Yang P, Chapkin RS. Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model. J Lipid Res. 2012;53:12875. 52. Turk HF, Kolar SS, Fan YY, Cozby CA, Lupton JR, Chapkin RS. Linoleic acid and butyrate synergize to raise Bcl-2 levels in colonocytes. Int J Cancer. 2011;128:631. 53. Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet D, Goldberg MV, Maris CH, et al. Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179:4313.Tomatine 54.Selpercatinib Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C.PMID:23812309 STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007;282:93583. 55. Bettelli E, Korn T, Oukka M, Kuchroo VK. Induction and effector functions of T(H)17 cells. Nature. 2008;453:1051. 56. Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, et al. Vital regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 2009;30:5767. 57. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, et al. T helper 17 lineage58.59.60.61.62.63.64.65.66.67.68. 69. 70.differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity. 2008;28:299. Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M. The improvement of inflammatory T(H)-17 cells calls for interferon-regulatory factor 4. Nat Immunol. 2007;8:9586. Chen Q, Yang W, Gupta S, Biswas P, Smith P, Bhagat G, Pernis AB. IRF4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity. 2008;29:89911. Kimura A, Naka T, Nohara K, Fujii-Kuriyama Y, Kishimoto T. Ar.