E standard swallowing group and these having a score 2 (two or fewer swallows in 30 seconds) into the impaired swallowing group. Abbreviation: rssT, repetitive saliva swallowing Test.Patient Preference and Adherence 2014:submit your manuscript | www.dovepressDovepressnakamura et alDovepress 5. Wimo A, Winblad B, Shah SN, et al. Effect of donepezil therapy for Alzheimer’s disease on caregiver time. Curr Med Res Opin. 2004;20: 1221225. six. Arai Y, Tamiya N, Yano E. [The brief version in the Japanese version on the Zarit Caregiver Burden Interview (J-ZBI_8): its reliability and validity]. Nihon Ronen Igakkai Zasshi. 2003;40:49703. Japanese. 7. Arai Y, Kudo K, Hosokawa T, et al. Reliability and validity of the Japanese version with the Zarit Caregiver Burden interview. Psychitry Clin Neurosci. 1997;51:28187. eight. Hashimoto M, Yatabe Y, Kaneda K, et al. Influence of donepezil hydrochloride around the care burden of family members caregivers of sufferers with Alzheimer’s disease. Psychogeriatrics. 2009;9:19603. 9. Robert H, Rupert M, James L, et al. Donepezil and memantine for moderate-to-severe Alzheimer’s illness. N Engl J Med. 2012;366: 89303. 10. Susan LM, Joan MT, Dan KK, et al. The clinical course of advanced dementia. N Engl J Med. 2009;361:1529538. 11. Kuzuya M, Enoki H, Izawa S, et al. Prevalence of oral intake difficulty and connected aspects in disabled elderly. The Journal of Japanese Society for Parenteral and Enteral Nutrition. 2011;26:1265270. 12. Wasson K, Tate H, Hayes C. Food refusal and dysphagia in older persons with dementia: ethical and sensible issues. Int J Palliat Nurs. 2001; 7:4651. 13. Reisberg B. Functional assessment staging (Fast). Psychopharmacol Bull. 1988;24:65359. 14. Oguchi K, Saitoh E, Mizuno M, et al. The Repetitive Saliva Swallowing Test (RSST) as a screening test of functional dysphagia. (1) Standard values of RSST. Jpn J Rehabil Med. 2000;37:37582. 15. Oguchi K, Saitoh E, Baba M, et al. The Repetitive Saliva Swallowing Test (RSST) as a screening test of functional dysphagia (2) Validity of RSST. Jpn J Rehabil Med. 2000;37:38388. 16. Kotani S, Yamauchi T, Teramoto T, et al. Pharmacological proof of cholinergic involvement in adult hippocampal neurogenesis in rats. Neuroscience. 2006;142:50514. 17. Tsubouchi T, Tsujimoto S, Sugimoto S, et al. Swallowing disorder and inhibition of cough reflex induced by atropine sulfate in conscious dogs.Mezigdomide J Pharmacol Sci.Parsaclisib 2008;106:45259.PMID:24140575 18. Stoschus B, Allescher D. Drug-induced dysphagia. Dysphagia. 1993;8: 15459. 19. Watanabe N, Yamamura K, Suzuki Y, et al. Pharmacist-based donepezil outpatient consultation service to improve medication persistence. Patient Choose Adherence. 2012;six:60511.Dementia is a progressive illness, so it really is difficult to cease its progression simply by increasing the donepezil dosage, regardless of its ability to temporarily increase symptoms. Similarly, caregiver burden could possibly be temporarily reduced by escalating the dosage, but the burden will boost once again because the AD patient’s symptoms progress. Thus, it’s necessary to deliver continuous long-term help for AD individuals and their caregivers. Part of the part of pharmacists is to provide assistance on medication adherence to AD individuals and their caregivers as part of management of medication.19 Multidisciplinary teams composed of specialists from distinctive disciplines, like neighborhood public well being, medicine, and social welfare, are also needed to supply such assistance. According to the results of this study, a checklist of AD.