Product Name :
SAR502250
Description:
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD).
CAS:
503860-57-9
Molecular Weight:
367.38
Formula:
C19H18FN5O2
Chemical Name:
2-[(2S)-2-(4-fluorophenyl)morpholin-4-yl]-1-methyl-1,6-dihydro-[4,4′-bipyrimidin]-6-one
Smiles :
CN1C(=NC(=CC1=O)C1=CC=NC=N1)N1CCO[C@H](C1)C1C=CC(F)=CC=1
InChiKey:
NKUNFNVAHJNALA-QGZVFWFLSA-N
InChi :
InChI=1S/C19H18FN5O2/c1-24-18(26)10-16(15-6-7-21-12-22-15)23-19(24)25-8-9-27-17(11-25)13-2-4-14(20)5-3-13/h2-7,10,12,17H,8-9,11H2,1H3/t17-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{AZ505 ditrifluoroacetate} web|{AZ505 ditrifluoroacetate} Epigenetics|{AZ505 ditrifluoroacetate} Purity & Documentation|{AZ505 ditrifluoroacetate} Purity|{AZ505 ditrifluoroacetate} manufacturer|{AZ505 ditrifluoroacetate} Autophagy}
Additional information:
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD).|Product information|CAS Number: 503860-57-9|Molecular Weight: 367.38|Formula: C19H18FN5O2|Chemical Name: 2-[(2S)-2-(4-fluorophenyl)morpholin-4-yl]-1-methyl-1,6-dihydro-[4,4′-bipyrimidin]-6-one|Smiles: CN1C(=NC(=CC1=O)C1=CC=NC=N1)N1CCO[C@H](C1)C1C=CC(F)=CC=1|InChiKey: NKUNFNVAHJNALA-QGZVFWFLSA-N|InChi: InChI=1S/C19H18FN5O2/c1-24-18(26)10-16(15-6-7-21-12-22-15)23-19(24)25-8-9-27-17(11-25)13-2-4-14(20)5-3-13/h2-7,10,12,17H,8-9,11H2,1H3/t17-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (272.{{Diclofenac} MedChemExpress|{Diclofenac} Apoptosis|{Diclofenac} Biological Activity|{Diclofenac} Purity|{Diclofenac} custom synthesis|{Diclofenac} Autophagy} 20 mM; Need ultrasonic).PMID:24275718 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons.|In Vivo:|SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mice expressing P301L tau. SAR502250 (10-30 mg/kg; p.o. once daily for 7 weeks) improves the cognitive deficit in transgenic APP(SW)/Tau(VLW) mice after infusion of Aβ25-35. SAR502250 (10-30 mg/kg; a single p.o.) significantly increases the percentage of lever-presses in the inter-response time (IRT) bin (49-96 s), with a significant augmentation of the percentage of reinforced responses. SAR502250 (30 mg/kg; i.p. once daily for 28 d) ameliorates chronic stress-induced degradation of the physical state of the mice coat. SAR502250 (10-60 mg/kg; a single p.o.) decreases hyperactivity produced by psychostimulantsin mice.|Products are for research use only. Not for human use.|