Product Name :
Acetoacetic acid sodium salt
Description:
Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes.
CAS:
623-58-5
Molecular Weight:
124.07
Formula:
C4H5NaO3
Chemical Name:
sodium 3-oxobutanoate
Smiles :
[Na+].CC(=O)CC([O-])=O
InChiKey:
UAKCMIIOSJFOTD-UHFFFAOYSA-M
InChi :
InChI=1S/C4H6O3.Na/c1-3(5)2-4(6)7;/h2H2,1H3,(H,6,7);/q;+1/p-1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes.|Product information|CAS Number: 623-58-5|Molecular Weight: 124.07|Formula: C4H5NaO3|Chemical Name: sodium 3-oxobutanoate|Smiles: [Na+].CC(=O)CC([O-])=O|InChiKey: UAKCMIIOSJFOTD-UHFFFAOYSA-M|InChi: InChI=1S/C4H6O3.Na/c1-3(5)2-4(6)7;/h2H2,1H3,(H,6,7);/q;+1/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 50 mg/mL (403.{{DiI} medchemexpress|{DiI} {Fluorescent Dye}|{DiI} Technical Information|{DiI} Purity|{DiI} manufacturer|{DiI} Epigenetics} 00 mM; Need ultrasonic).{{AUDA} medchemexpress|{AUDA} Epoxide Hydrolase|{AUDA} Biological Activity|{AUDA} In Vivo|{AUDA} supplier|{AUDA} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24189672 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH) group, decreases mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in all groups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition, Acetoacetic acid down-regulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG) accumulation is increased in these bovine hepatocytes.|Products are for research use only. Not for human use.|