Product Name :
DI-82
Description:
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity.
CAS:
1638148-50-1
Molecular Weight:
510.65
Formula:
C20H26N6O4S3
Chemical Name:
N-[2-(5-{4-[(1R)-1-[(4,6-diaminopyrimidin-2-yl)sulfanyl]ethyl]-5-methyl-1,3-thiazol-2-yl}-2-methoxyphenoxy)ethyl]methanesulfonamide
Smiles :
CC1SC(=NC=1[C@@H](C)SC1N=C(N)C=C(N)N=1)C1=CC(OCCNS(C)(=O)=O)=C(C=C1)OC
InChiKey:
MBPWFMBRNJJXFY-GFCCVEGCSA-N
InChi :
InChI=1S/C20H26N6O4S3/c1-11-18(12(2)32-20-24-16(21)10-17(22)25-20)26-19(31-11)13-5-6-14(29-3)15(9-13)30-8-7-23-33(4,27)28/h5-6,9-10,12,23H,7-8H2,1-4H3,(H4,21,22,24,25)/t12-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Mitochondria Isolation Kit for Cultured Cells} web|{Mitochondria Isolation Kit for Cultured Cells} Protocol|{Mitochondria Isolation Kit for Cultured Cells} Description|{Mitochondria Isolation Kit for Cultured Cells} custom synthesis|{Mitochondria Isolation Kit for Cultured Cells} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.{{Orexin 2 Receptor Agonist} site|{Orexin 2 Receptor Agonist} Orexin Receptor (OX Receptor)|{Orexin 2 Receptor Agonist} Protocol|{Orexin 2 Receptor Agonist} Purity|{Orexin 2 Receptor Agonist} supplier|{Orexin 2 Receptor Agonist} Epigenetic Reader Domain} 2 nM.PMID:32695810 DI-82 has antitumor activity.|Product information|CAS Number: 1638148-50-1|Molecular Weight: 510.65|Formula: C20H26N6O4S3|Chemical Name: N-[2-(5-{4-[(1R)-1-[(4,6-diaminopyrimidin-2-yl)sulfanyl]ethyl]-5-methyl-1,3-thiazol-2-yl}-2-methoxyphenoxy)ethyl]methanesulfonamide|Smiles: CC1SC(=NC=1[C@@H](C)SC1N=C(N)C=C(N)N=1)C1=CC(OCCNS(C)(=O)=O)=C(C=C1)OC|InChiKey: MBPWFMBRNJJXFY-GFCCVEGCSA-N|InChi: InChI=1S/C20H26N6O4S3/c1-11-18(12(2)32-20-24-16(21)10-17(22)25-20)26-19(31-11)13-5-6-14(29-3)15(9-13)30-8-7-23-33(4,27)28/h5-6,9-10,12,23H,7-8H2,1-4H3,(H4,21,22,24,25)/t12-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DI-82 (compound 12R) has an IC50 of 3.7 nM in CCRF-CEM acute lymphoblastic leukemia cells. DI-82 (1 μM) has a NADPH-dependent CLint of 22.7 μL/min•mg and a NADPH-dependent T1/2 of 102 mins in a standard microsomal liver clearance assay. DI-82 (200 μM) completely blunts the ability of decitabine to bind human thymidylate synthase (TS).|Products are for research use only. Not for human use.|