Product Name :
TXNIP-IN-1
Description:
TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.
CAS:
1268955-50-5
Molecular Weight:
248.23
Formula:
C12H12N2O4
Chemical Name:
2-{1,3-dioxo-1H,2H,3H-pyrrolo[3,4-c]pyridin-2-yl}-3-methylbutanoic acid
Smiles :
CC(C)C(C(O)=O)N1C(=O)C2=CC=NC=C2C1=O
InChiKey:
KTDYLXVLROCGRL-UHFFFAOYSA-N
InChi :
InChI=1S/C12H12N2O4/c1-6(2)9(12(17)18)14-10(15)7-3-4-13-5-8(7)11(14)16/h3-6,9H,1-2H3,(H,17,18)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.|Product information|CAS Number: 1268955-50-5|Molecular Weight: 248.23|Formula: C12H12N2O4|Chemical Name: 2-{1,3-dioxo-1H,2H,3H-pyrrolo[3,4-c]pyridin-2-yl}-3-methylbutanoic acid|Smiles: CC(C)C(C(O)=O)N1C(=O)C2=CC=NC=C2C1=O|InChiKey: KTDYLXVLROCGRL-UHFFFAOYSA-N|InChi: InChI=1S/C12H12N2O4/c1-6(2)9(12(17)18)14-10(15)7-3-4-13-5-8(7)11(14)16/h3-6,9H,1-2H3,(H,17,18)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (201.43 mM; Need ultrasonic).{{Menin-MLL inhibitor 21} web|{Menin-MLL inhibitor 21} JAK/STAT Signaling|{Menin-MLL inhibitor 21} Technical Information|{Menin-MLL inhibitor 21} Description|{Menin-MLL inhibitor 21} manufacturer|{Menin-MLL inhibitor 21} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Phenytoin} site|{Phenytoin} Virus Protease|{Phenytoin} Biological Activity|{Phenytoin} In Vivo|{Phenytoin} manufacturer|{Phenytoin} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:24103058 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TXNIP-IN-1 bocks high glucose (HG induced) TXNIP-TRX complex formation. TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF in monocytes. TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression in THP1 cells. TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages. TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels in MIN6 cells. TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in human pancreas 1.1B4 beta cells. TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose. TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets.|Products are for research use only. Not for human use.|