Product Name :
DHODH-IN-1
Description:
DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway.
CAS:
1800296-63-2
Molecular Weight:
403.40
Formula:
C21H20F3N3O2
Chemical Name:
5-cyclopropyl-2-[4-(2,6-difluorophenoxy)-5-methyl-3-(propan-2-yloxy)-1H-pyrazol-1-yl]-3-fluoropyridine
Smiles :
CC1=C(OC2C(F)=CC=CC=2F)C(=NN1C1=NC=C(C=C1F)C1CC1)OC(C)C
InChiKey:
JNAABFZPXJJMPX-UHFFFAOYSA-N
InChi :
InChI=1S/C21H20F3N3O2/c1-11(2)28-21-18(29-19-15(22)5-4-6-16(19)23)12(3)27(26-21)20-17(24)9-14(10-25-20)13-7-8-13/h4-6,9-11,13H,7-8H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway.|Product information|CAS Number: 1800296-63-2|Molecular Weight: 403.40|Formula: C21H20F3N3O2|Chemical Name: 5-cyclopropyl-2-[4-(2,6-difluorophenoxy)-5-methyl-3-(propan-2-yloxy)-1H-pyrazol-1-yl]-3-fluoropyridine|Smiles: CC1=C(OC2C(F)=CC=CC=2F)C(=NN1C1=NC=C(C=C1F)C1CC1)OC(C)C|InChiKey: JNAABFZPXJJMPX-UHFFFAOYSA-N|InChi: InChI=1S/C21H20F3N3O2/c1-11(2)28-21-18(29-19-15(22)5-4-6-16(19)23)12(3)27(26-21)20-17(24)9-14(10-25-20)13-7-8-13/h4-6,9-11,13H,7-8H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tozorakimab} MedChemExpress|{Tozorakimab} Immunology/Inflammation|{Tozorakimab} Technical Information|{Tozorakimab} Purity|{Tozorakimab} custom synthesis|{Tozorakimab} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Cefoperazone} site|{Cefoperazone} Antibiotic|{Cefoperazone} Technical Information|{Cefoperazone} In stock|{Cefoperazone} manufacturer|{Cefoperazone} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24463635 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM). DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells. DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules.|In Vivo:|DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min.|Products are for research use only. Not for human use.|