Product Name :
iP300w
Description:
Potent p300/CBP inhibitor. Inhibits p300-mediated H3K9 acetylation (IC50 = 33 nM). Inhibits cytotoxicity of DUX4 and overexpression of DUX4 target genes in vitro. Also impairs DUX4-mediated transcription in an animal model of facioscapulohumeral muscular dystrophy
CAS:
Molecular Weight:
618.55
Formula:
C29H27F5N6O4
Chemical Name:
2-(3′-fluoro-5′-{1-[(methylcarbamoyl)methyl]-1H-pyrazol-4-yl}-2, 5-dioxo-2′, 3′-dihydrospiro[imidazolidine-4, 1′-inden]-1-yl)-N-[(4-fluorophenyl)methyl]-N-(1, 1, 1-trifluoropropan-2-yl)acetamide
Smiles :
CC(N(CC1=CC=C(F)C=C1)C(=O)CN1C(=O)C2(CC(F)C3=CC(=CC=C23)C2=CN(CC(=O)NC)N=C2)NC1=O)C(F)(F)F
InChiKey:
SWXCHCQCWFXILM-UHFFFAOYSA-N
InChi :
InChI=1S/C29H27F5N6O4/c1-16(29(32,33)34)39(12-17-3-6-20(30)7-4-17)25(42)15-40-26(43)28(37-27(40)44)10-23(31)21-9-18(5-8-22(21)28)19-11-36-38(13-19)14-24(41)35-2/h3-9,11,13,16,23H,10,12,14-15H2,1-2H3,(H,35,41)(H,37,44)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Potent p300/CBP inhibitor. Inhibits p300-mediated H3K9 acetylation (IC50 = 33 nM). Inhibits cytotoxicity of DUX4 and overexpression of DUX4 target genes in vitro. Also impairs DUX4-mediated transcription in an animal model of facioscapulohumeral muscular dystrophy|Product information|Molecular Weight: 618.55|Formula: C29H27F5N6O4|Chemical Name: 2-(3′-fluoro-5′-{1-[(methylcarbamoyl)methyl]-1H-pyrazol-4-yl}-2, 5-dioxo-2′, 3′-dihydrospiro[imidazolidine-4, 1′-inden]-1-yl)-N-[(4-fluorophenyl)methyl]-N-(1, 1, 1-trifluoropropan-2-yl)acetamide|Smiles: CC(N(CC1=CC=C(F)C=C1)C(=O)CN1C(=O)C2(CC(F)C3=CC(=CC=C23)C2=CN(CC(=O)NC)N=C2)NC1=O)C(F)(F)F|InChiKey: SWXCHCQCWFXILM-UHFFFAOYSA-N|InChi: InChI=1S/C29H27F5N6O4/c1-16(29(32,33)34)39(12-17-3-6-20(30)7-4-17)25(42)15-40-26(43)28(37-27(40)44)10-23(31)21-9-18(5-8-22(21)28)19-11-36-38(13-19)14-24(41)35-2/h3-9,11,13,16,23H,10,12,14-15H2,1-2H3,(H,35,41)(H,37,44)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Pretomanid} medchemexpress|{Pretomanid} Bacterial|{Pretomanid} Biological Activity|{Pretomanid} In Vivo|{Pretomanid} supplier|{Pretomanid} Autophagy} |Shelf Life: ≥12 months if stored properly.{{TAT peptide} site|{TAT peptide} Anti-infection|{TAT peptide} Protocol|{TAT peptide} Data Sheet|{TAT peptide} manufacturer|{TAT peptide} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:27217159 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Bosnakovski D, da Silva MT, Sunny ST, et al. A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death. Sci Adv. 2019;5(9):eaaw7781. Published 2019 Sep 11. doi:10.1126/sciadv.aaw7781Products are for research use only. Not for human use.|