Product Name :
Tyk2-IN-9
Description:
Tyk2-IN-9 is a potent,selective and specific inhibitor of JAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6 nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US2017240552A1.
CAS:
2127109-85-5
Molecular Weight:
383.41
Formula:
C20H17N9
Chemical Name:
3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutane-1-carbonitrile
Smiles :
CN1C=C(C=N1)C1=CN2N=CC=C2C(=N1)C1=CN(N=C1)C1(CC#N)CC(C1)C#N
InChiKey:
XPLZTJWZDBFWDE-UHFFFAOYSA-N
InChi :
InChI=1S/C20H17N9/c1-27-11-15(9-24-27)17-13-28-18(2-5-23-28)19(26-17)16-10-25-29(12-16)20(3-4-21)6-14(7-20)8-22/h2,5,9-14H,3,6-7H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tyk2-IN-9 is a potent,selective and specific inhibitor of JAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6 nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US2017240552A1.|Product information|CAS Number: 2127109-85-5|Molecular Weight: 383.41|Formula: C20H17N9|Chemical Name: 3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutane-1-carbonitrile|Smiles: CN1C=C(C=N1)C1=CN2N=CC=C2C(=N1)C1=CN(N=C1)C1(CC#N)CC(C1)C#N|InChiKey: XPLZTJWZDBFWDE-UHFFFAOYSA-N|InChi: InChI=1S/C20H17N9/c1-27-11-15(9-24-27)17-13-28-18(2-5-23-28)19(26-17)16-10-25-29(12-16)20(3-4-21)6-14(7-20)8-22/h2,5,9-14H,3,6-7H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 3.{{Bedaquiline} site|{Bedaquiline} Bacterial|{Bedaquiline} Protocol|{Bedaquiline} Formula|{Bedaquiline} supplier|{Bedaquiline} Autophagy} 33 mg/mL (8.{{Nebivolol} medchemexpress|{Nebivolol} Neuronal Signaling|{Nebivolol} Purity & Documentation|{Nebivolol} References|{Nebivolol} manufacturer|{Nebivolol} Autophagy} 69 mM; ultrasonic and adjust pH to 4 with HCl).PMID:28322188 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tyk2-IN-9 has the ability to inhibit IL-12 signaling in a human whole blood with an IC50 value of 28 nM in a flow cytometry assay.|Products are for research use only. Not for human use.|