Product Name :
BRD-K98645985
Description:
BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity.
CAS:
1357647-78-9
Molecular Weight:
573.73
Formula:
C33H43N5O4
Chemical Name:
1-[(3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-{[4-(pyridin-2-yl)phenyl]methyl}-3,4,5,6,7,8,9,10-octahydro-2H-1,4,9-benzoxadiazacyclododecin-12-yl]-3-(propan-2-yl)urea
Smiles :
CN1C[C@H](OC)[C@@H](C)CN(CC2C=CC(=CC=2)C2C=CC=CN=2)[C@@H](C)COC2=CC=C(C=C2C1=O)NC(=O)NC(C)C
InChiKey:
DZGZFXRKNSZUSK-MKGJDZFWSA-N
InChi :
InChI=1S/C33H43N5O4/c1-22(2)35-33(40)36-27-14-15-30-28(17-27)32(39)37(5)20-31(41-6)23(3)18-38(24(4)21-42-30)19-25-10-12-26(13-11-25)29-9-7-8-16-34-29/h7-17,22-24,31H,18-21H2,1-6H3,(H2,35,36,40)/t23-,24-,31-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity.|Product information|CAS Number: 1357647-78-9|Molecular Weight: 573.73|Formula: C33H43N5O4|Chemical Name: 1-[(3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-{[4-(pyridin-2-yl)phenyl]methyl}-3,4,5,6,7,8,9,10-octahydro-2H-1,4,9-benzoxadiazacyclododecin-12-yl]-3-(propan-2-yl)urea|Smiles: CN1C[C@H](OC)[C@@H](C)CN(CC2C=CC(=CC=2)C2C=CC=CN=2)[C@@H](C)COC2=CC=C(C=C2C1=O)NC(=O)NC(C)C|InChiKey: DZGZFXRKNSZUSK-MKGJDZFWSA-N|InChi: InChI=1S/C33H43N5O4/c1-22(2)35-33(40)36-27-14-15-30-28(17-27)32(39)37(5)20-31(41-6)23(3)18-38(24(4)21-42-30)19-25-10-12-26(13-11-25)29-9-7-8-16-34-29/h7-17,22-24,31H,18-21H2,1-6H3,(H2,35,36,40)/t23-,24-,31-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (435.{{Chlorthalidone} MedChemExpress|{Chlorthalidone} Protocol|{Chlorthalidone} In Vivo|{Chlorthalidone} manufacturer|{Chlorthalidone} Autophagy} 75 mM; Need ultrasonic).{{M-CSF Protein, Mouse} web|{M-CSF Protein, Mouse} Purity & Documentation|{M-CSF Protein, Mouse} Data Sheet|{M-CSF Protein, Mouse} manufacturer|{M-CSF Protein, Mouse} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24516446 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BRD-K98645985 (30 µM; 18 hours) treatment shows a 5-fold increase in Bmi1, 2.6-fold increase in Ring1, and 3.3-fold decrease in Fgf4. BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting.|References:|Marian CA, et al. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.Products are for research use only. Not for human use.|