Product Name :
IM-54
Description:
IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death.
CAS:
861891-50-1
Molecular Weight:
325.40
Formula:
C19H23N3O2
Chemical Name:
1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-2,5-dihydro-1H-pyrrole-2,5-dione
Smiles :
CCCCCNC1=C(C2=CN(C)C3=CC=CC=C23)C(=O)N(C)C1=O
InChiKey:
SGLOMINNEBLJFF-UHFFFAOYSA-N
InChi :
InChI=1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)22(3)19(17)24)14-12-21(2)15-10-7-6-9-13(14)15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis.{{DPN} MedChemExpress|{DPN} Vitamin D Related/Nuclear Receptor|{DPN} Biological Activity|{DPN} In Vivo|{DPN} manufacturer|{DPN} Epigenetics} IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death.{{Tetrahydroberberine} medchemexpress|{Tetrahydroberberine} Neuronal Signaling|{Tetrahydroberberine} Purity & Documentation|{Tetrahydroberberine} In Vitro|{Tetrahydroberberine} manufacturer|{Tetrahydroberberine} Autophagy} |Product information|CAS Number: 861891-50-1|Molecular Weight: 325.40|Formula: C19H23N3O2|Chemical Name: 1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-2,5-dihydro-1H-pyrrole-2,5-dione|Smiles: CCCCCNC1=C(C2=CN(C)C3=CC=CC=C23)C(=O)N(C)C1=O|InChiKey: SGLOMINNEBLJFF-UHFFFAOYSA-N|InChi: InChI=1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)22(3)19(17)24)14-12-21(2)15-10-7-6-9-13(14)15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24238102 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|IM-54 selectively inhibits oxidative stress-induced necrosis, but it does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis. IM-54 shows strong inhibition of H2O2-induced necrosis, with an IC50 of 0.25 μM in HL-60 cells.|Products are for research use only. Not for human use.|