Product Name :
BioE-1115
Description:
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.
CAS:
1268863-35-9
Molecular Weight:
339.36
Formula:
C19H18FN3O2
Chemical Name:
2-(4-fluorophenyl)-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxylic acid
Smiles :
CC(C)N(C)C1=NC2=CC(=CC=C2N=C1C1C=CC(F)=CC=1)C(O)=O
InChiKey:
JKKRYYTVQXUOKL-UHFFFAOYSA-N
InChi :
InChI=1S/C19H18FN3O2/c1-11(2)23(3)18-17(12-4-7-14(20)8-5-12)21-15-9-6-13(19(24)25)10-16(15)22-18/h4-11H,1-3H3,(H,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.|Product information|CAS Number: 1268863-35-9|Molecular Weight: 339.36|Formula: C19H18FN3O2|Chemical Name: 2-(4-fluorophenyl)-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxylic acid|Smiles: CC(C)N(C)C1=NC2=CC(=CC=C2N=C1C1C=CC(F)=CC=1)C(O)=O|InChiKey: JKKRYYTVQXUOKL-UHFFFAOYSA-N|InChi: InChI=1S/C19H18FN3O2/c1-11(2)23(3)18-17(12-4-7-14(20)8-5-12)21-15-9-6-13(19(24)25)10-16(15)22-18/h4-11H,1-3H3,(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.5 mg/mL (184.17 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Doravirine} site|{Doravirine} HIV|{Doravirine} Purity & Documentation|{Doravirine} In stock|{Doravirine} custom synthesis|{Doravirine} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Amifampridine} MedChemExpress|{Amifampridine} Potassium Channel|{Amifampridine} Purity & Documentation|{Amifampridine} In Vitro|{Amifampridine} supplier|{Amifampridine} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24507727 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In the presence of BioE-1115, shows a dose-dependent loss of PASK phosphorylation, with an IC50 of ~1μM in HEK293 cells. At the concentrations above 10μM, BioE-1115 treatment shows a significant reduction in SREBP activity, without any observable effects on cell morphology or growth rate in HepG2 cells.|In Vivo:|BioE-1115 (1-100 mg/kg; oral gavage; daily; for 7 days; male Sprague-Dawley rats) treatment shows a dose-dependent suppression of the expression of Gpat1, Fasn and all other SREBP-1c target genes analyzed. SREBP-1 maturation in liver is also suppressed in BioE-1115 treated rats at 10, 30 and 100 mg/kg doses. A calculated measure of insulin resistance, HOMA-IR, is decreased in a dose-dependent manner by BioE-1115 administration. Hepatic and serum TAG are decreased in a dose-dependent manner by BioE-1115 administration. BioE-1115 treatment causes a significant decrease in serum glucose. Both SREBP-1c and SREBP-1a mRNA are modestly decreased at the highest doses. Neither dose of BioE-1115 causes a significant change in either liver weight or body weight.|Products are for research use only. Not for human use.|