Product Name :
Ruboxistaurin-d6 hydrochloride
Description:
Ruboxistaurin-d6 (LY333531-d6) hydrochloride is the deuterium labeled Ruboxistaurin hydrochloride. Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC50 of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC50 of 5.9 nM.
CAS:
1794767-04-6
Molecular Weight:
511.04
Formula:
C28H29ClN4O3
Chemical Name:
(18S)-18-{[di(²H₃)methylamino]methyl}-17-oxa-4,14,21-triazahexacyclo[19.{{Doxazosin} MedChemExpress|{Doxazosin} Autophagy|{Doxazosin} Protocol|{Doxazosin} Data Sheet|{Doxazosin} custom synthesis|{Doxazosin} Epigenetic Reader Domain} 6.1.1⁷,¹⁴.0²,⁶.0⁸,¹³.0²²,²⁷]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione hydrochloride
Smiles :
Cl.[2H]C([2H])([2H])N(C[C@@H]1CCN2C=C(C3=C(C4=CN(CCO1)C1=CC=CC=C14)C(=O)NC3=O)C1=CC=CC=C21)C([2H])([2H])[2H]
InChiKey:
NYQIEYDJYFVLPO-DOVGNSRXSA-N
InChi :
InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1/i1D3,2D3;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Ruboxistaurin-d6 (LY333531-d6) hydrochloride is the deuterium labeled Ruboxistaurin hydrochloride. Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM).{{DM3} site|{DM3} Cell Cycle/DNA Damage|{DM3} Purity & Documentation|{DM3} In stock|{DM3} manufacturer|{DM3} Autophagy} Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC50 of 4.PMID:24101108 7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC50 of 5.9 nM.|Product information|CAS Number: 1794767-04-6|Molecular Weight: 511.04|Formula: C28H29ClN4O3|Chemical Name: (18S)-18-{[di(²H₃)methylamino]methyl}-17-oxa-4,14,21-triazahexacyclo[19.6.1.1⁷,¹⁴.0²,⁶.0⁸,¹³.0²²,²⁷]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione hydrochloride|Smiles: Cl.[2H]C([2H])([2H])N(C[C@@H]1CCN2C=C(C3=C(C4=CN(CCO1)C1=CC=CC=C14)C(=O)NC3=O)C1=CC=CC=C21)C([2H])([2H])[2H]|InChiKey: NYQIEYDJYFVLPO-DOVGNSRXSA-N|InChi: InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1/i1D3,2D3;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.|Products are for research use only. Not for human use.|