Product Name :
Mal-amido-PEG2-TFP ester
Description:
Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
CAS:
1431291-44-9
Molecular Weight:
476.38
Formula:
C20H20F4N2O7
Chemical Name:
2,3,5,6-tetrafluorophenyl 3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoate
Smiles :
O=C(CCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)OC1C(F)=C(F)C=C(F)C=1F
InChiKey:
HHXSYLTYQVHXMA-UHFFFAOYSA-N
InChi :
InChI=1S/C20H20F4N2O7/c21-12-11-13(22)19(24)20(18(12)23)33-17(30)4-7-31-9-10-32-8-5-25-14(27)3-6-26-15(28)1-2-16(26)29/h1-2,11H,3-10H2,(H,25,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Selenomethionine} web|{Selenomethionine} Metabolic Enzyme/Protease|{Selenomethionine} Purity & Documentation|{Selenomethionine} In stock|{Selenomethionine} manufacturer|{Selenomethionine} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Olodaterol} MedChemExpress|{Olodaterol} GPCR/G Protein|{Olodaterol} Biological Activity|{Olodaterol} Purity|{Olodaterol} manufacturer|{Olodaterol} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.PMID:25558565 |Product information|CAS Number: 1431291-44-9|Molecular Weight: 476.38|Formula: C20H20F4N2O7|Chemical Name: 2,3,5,6-tetrafluorophenyl 3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoate|Smiles: O=C(CCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)OC1C(F)=C(F)C=C(F)C=1F|InChiKey: HHXSYLTYQVHXMA-UHFFFAOYSA-N|InChi: InChI=1S/C20H20F4N2O7/c21-12-11-13(22)19(24)20(18(12)23)33-17(30)4-7-31-9-10-32-8-5-25-14(27)3-6-26-15(28)1-2-16(26)29/h1-2,11H,3-10H2,(H,25,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 150 mg/mL (314.87 mM; Need ultrasonic). H2O : 2.71 mg/mL (5.69 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|