Product Name :
MI-2, Menin-MLL Inhibitor
Description:
MI-2 is a potent and specific Menin-MLL inhibitor with an IC50 ~446 nM. It specifically binds to Menin and inhibits Menin’s interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion protein–mediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI-2 is a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of Menin as an oncogenic cofactor of MLL fusion proteins.
CAS:
1271738-62-5
Molecular Weight:
375.55
Formula:
C18H25N5S2
Chemical Name:
4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyrimidine
Smiles :
CCCC1=CC2=C(N=CN=C2S1)N1CCN(CC1)C1=NCC(C)(C)S1
InChiKey:
SRQYLNYQAPCPIR-UHFFFAOYSA-N
InChi :
InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MI-2 is a potent and specific Menin-MLL inhibitor with an IC50 ~446 nM. It specifically binds to Menin and inhibits Menin’s interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion protein–mediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity.{{Diosmin} site|{Diosmin} Aryl Hydrocarbon Receptor|{Diosmin} Purity & Documentation|{Diosmin} In Vivo|{Diosmin} supplier|{Diosmin} Epigenetics} MI-2 is a new tool for better understanding MLL-mediated leukemogenesis and represents a new approach for studying the role of Menin as an oncogenic cofactor of MLL fusion proteins.{{Amlodipine besylate} medchemexpress|{Amlodipine besylate} Calcium Channel|{Amlodipine besylate} Technical Information|{Amlodipine besylate} References|{Amlodipine besylate} custom synthesis|{Amlodipine besylate} Epigenetic Reader Domain} |Product information|CAS Number: 1271738-62-5|Molecular Weight: 375.PMID:24883330 55|Formula: C18H25N5S2|Chemical Name: 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyrimidine|Smiles: CCCC1=CC2=C(N=CN=C2S1)N1CCN(CC1)C1=NCC(C)(C)S1|InChiKey: SRQYLNYQAPCPIR-UHFFFAOYSA-N|InChi: InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|MI-2 was used at 10-25 µM concentration in vitro and in the cellular assays.|References:|Grembecka J, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. (2012) Nat Chem Biol. 8(3):277-84.Products are for research use only. Not for human use.|