Product Name :
PF-9366
Description:
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM.
CAS:
72882-78-1
Molecular Weight:
350.84
Formula:
C20H19ClN4
Chemical Name:
(2-{7-chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl}ethyl)dimethylamine
Smiles :
CN(C)CCC1=NN=C2C=C(C3=CC(Cl)=CC=C3N21)C1C=CC=CC=1
InChiKey:
LYLASWLQCMKZAT-UHFFFAOYSA-N
InChi :
InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM.|Product information|CAS Number: 72882-78-1|Molecular Weight: 350.{{Insulin degludec} MedChemExpress|{Insulin degludec} Protein Tyrosine Kinase/RTK|{Insulin degludec} Technical Information|{Insulin degludec} Formula|{Insulin degludec} custom synthesis|{Insulin degludec} Epigenetics} 84|Formula: C20H19ClN4|Chemical Name: (2-{7-chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl}ethyl)dimethylamine|Smiles: CN(C)CCC1=NN=C2C=C(C3=CC(Cl)=CC=C3N21)C1C=CC=CC=1|InChiKey: LYLASWLQCMKZAT-UHFFFAOYSA-N|InChi: InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (71.{{Patritumab} web|{Patritumab} Apoptosis|{Patritumab} Biological Activity|{Patritumab} Formula|{Patritumab} custom synthesis|{Patritumab} Epigenetic Reader Domain} 26 mM; Need ultrasonic).PMID:23329319 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PF-9366 is a Mat2A inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50 of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50 of 255 nM, and also suppresses the proliferation of cells with an IC50 of 10 μM.|Products are for research use only. Not for human use.|