Product Name :
NB-360
Description:
NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E.
CAS:
1262857-73-7
Molecular Weight:
449.40
Formula:
C21H19F4N5O2
Chemical Name:
N-{3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-cyano-3-methylpyridine-2-carboxamide
Smiles :
CC1=CC(=CN=C1C(=O)NC1C=C(C(F)=CC=1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N
InChiKey:
BQFHTVUWPJXLOW-VQTJNVASSA-N
InChi :
InChI=1S/C21H19F4N5O2/c1-11-6-12(8-26)9-28-16(11)17(31)29-13-4-5-15(22)14(7-13)19(2)10-32-20(3,18(27)30-19)21(23,24)25/h4-7,9H,10H2,1-3H3,(H2,27,30)(H,29,31)/t19-,20+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM).{{Fenoprofen} MedChemExpress|{Fenoprofen} Neuronal Signaling|{Fenoprofen} Purity & Documentation|{Fenoprofen} In Vivo|{Fenoprofen} custom synthesis|{Fenoprofen} Epigenetics} NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice.{{Antiflammin 2} MedChemExpress|{Antiflammin 2} Platelet-activating Factor Receptor (PAFR)|{Antiflammin 2} Protocol|{Antiflammin 2} Purity|{Antiflammin 2} custom synthesis|{Antiflammin 2} Autophagy} NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E.PMID:24580853 |Product information|CAS Number: 1262857-73-7|Molecular Weight: 449.40|Formula: C21H19F4N5O2|Chemical Name: N-{3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-cyano-3-methylpyridine-2-carboxamide|Smiles: CC1=CC(=CN=C1C(=O)NC1C=C(C(F)=CC=1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N|InChiKey: BQFHTVUWPJXLOW-VQTJNVASSA-N|InChi: InChI=1S/C21H19F4N5O2/c1-11-6-12(8-26)9-28-16(11)17(31)29-13-4-5-15(22)14(7-13)19(2)10-32-20(3,18(27)30-19)21(23,24)25/h4-7,9H,10H2,1-3H3,(H2,27,30)(H,29,31)/t19-,20+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|