Product Name :
Valnivudine
Description:
Valnivudine (FV-100 free base), a prodrug of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV). Valnivudine is rapidly and extensively converted to CF-1743 in vivo.
CAS:
956483-02-6
Molecular Weight:
497.58
Formula:
C27H35N3O6
Chemical Name:
[(2R,3S,5R)-3-hydroxy-5-[2-oxo-6-(4-pentylphenyl)-2H,3H-furo[2,3-d]pyrimidin-3-yl]oxolan-2-yl]methyl (2S)-2-amino-3-methylbutanoate
Smiles :
CC(C)[C@H](N)C(=O)OC[C@H]1O[C@H](C[C@@H]1O)N1C=C2C=C(OC2=NC1=O)C1=CC=C(CCCCC)C=C1
InChiKey:
FJRRWJMFUNGZBJ-RBVMOCNTSA-N
InChi :
InChI=1S/C27H35N3O6/c1-4-5-6-7-17-8-10-18(11-9-17)21-12-19-14-30(27(33)29-25(19)36-21)23-13-20(31)22(35-23)15-34-26(32)24(28)16(2)3/h8-12,14,16,20,22-24,31H,4-7,13,15,28H2,1-3H3/t20-,22+,23+,24-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Enoblituzumab} site|{Enoblituzumab} Technical Information|{Enoblituzumab} Formula|{Enoblituzumab} supplier|{Enoblituzumab} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Sacubitril/Valsartan} web|{Sacubitril/Valsartan} Neprilysin|{Sacubitril/Valsartan} Technical Information|{Sacubitril/Valsartan} Data Sheet|{Sacubitril/Valsartan} custom synthesis|{Sacubitril/Valsartan} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Valnivudine (FV-100 free base), a prodrug of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV).PMID:24282960 Valnivudine is rapidly and extensively converted to CF-1743 in vivo.|Product information|CAS Number: 956483-02-6|Molecular Weight: 497.58|Formula: C27H35N3O6|Chemical Name: [(2R,3S,5R)-3-hydroxy-5-[2-oxo-6-(4-pentylphenyl)-2H,3H-furo[2,3-d]pyrimidin-3-yl]oxolan-2-yl]methyl (2S)-2-amino-3-methylbutanoate|Smiles: CC(C)[C@H](N)C(=O)OC[C@H]1O[C@H](C[C@@H]1O)N1C=C2C=C(OC2=NC1=O)C1=CC=C(CCCCC)C=C1|InChiKey: FJRRWJMFUNGZBJ-RBVMOCNTSA-N|InChi: InChI=1S/C27H35N3O6/c1-4-5-6-7-17-8-10-18(11-9-17)21-12-19-14-30(27(33)29-25(19)36-21)23-13-20(31)22(35-23)15-34-26(32)24(28)16(2)3/h8-12,14,16,20,22-24,31H,4-7,13,15,28H2,1-3H3/t20-,22+,23+,24-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (100.49 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In vitro cytotoxicity studies in normal human primary hepatocytes, keratinocytes, and rapidly dividing HepG2 cells, Valnivudine (FV-100 free base) demonstrates mean 50% cytotoxic concentration values of >10 μM. CF-1743 (compound 4f) has anti-varicella-zoster virus (VZV) activity in VZV OKA (EC50=0.3 nM), VZV YS (EC50=0.1 nM) in HEL cell.|Products are for research use only. Not for human use.|