Product Name :
sulfo-DGN462 sodium
Description:
sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).
CAS:
1401203-09-5
Molecular Weight:
1046.19
Formula:
C53H60N5NaO12S2
Chemical Name:
(12S, 12aS)-9-((3-((2-mercapto-2-methylpropyl)(2-(2-(2-methoxyethoxy)ethoxy)ethyl)amino)-5-((((S)-8-methoxy-6-oxo-11, 12, 12a, 13-tetrahydro-6H-benzo[5, 6][1, 4]diazepino[1, 2-a]indol-9-yl)oxy)methyl)benzyl)oxy)-8-methoxy-6-oxo-11, 12, 12a, 13-tetrahydro-6H-benzo[5, 6][1, 4]diazepino[1, 2-a]indole-12-sulfonate
Smiles :
[Na+].COCCOCCOCCN(CC(C)(C)S)C1=CC(COC2=CC3N[C@H]([C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)S([O-])(=O)=O)=CC(COC2=CC3NC[C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)=C1
InChiKey:
RNHTWDMUNIEDKX-ORJPSMTCSA-M
InChi :
InChI=1S/C53H61N5O12S2.Na/c1-53(2,71)32-56(14-15-67-18-19-68-17-16-64-3)37-21-33(30-69-48-27-41-39(25-46(48)65-4)51(59)57-38(29-54-41)23-35-10-6-8-12-43(35)57)20-34(22-37)31-70-49-28-42-40(26-47(49)66-5)52(60)58-44-13-9-7-11-36(44)24-45(58)50(55-42)72(61,62)63;/h6-13,20-22,25-28,38,45,50,54-55,71H,14-19,23-24,29-32H2,1-5H3,(H,61,62,63);/q;+1/p-1/t38-,45-,50-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Nystatin} medchemexpress|{Nystatin} Fungal|{Nystatin} Technical Information|{Nystatin} Data Sheet|{Nystatin} custom synthesis|{Nystatin} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Cabazitaxel} site|{Cabazitaxel} Microtubule/Tubulin|{Cabazitaxel} Biological Activity|{Cabazitaxel} Formula|{Cabazitaxel} supplier|{Cabazitaxel} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:27108903
Additional information:
sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).|Product information|CAS Number: 1401203-09-5|Molecular Weight: 1046.19|Formula: C53H60N5NaO12S2|Chemical Name: (12S, 12aS)-9-((3-((2-mercapto-2-methylpropyl)(2-(2-(2-methoxyethoxy)ethoxy)ethyl)amino)-5-((((S)-8-methoxy-6-oxo-11, 12, 12a, 13-tetrahydro-6H-benzo[5, 6][1, 4]diazepino[1, 2-a]indol-9-yl)oxy)methyl)benzyl)oxy)-8-methoxy-6-oxo-11, 12, 12a, 13-tetrahydro-6H-benzo[5, 6][1, 4]diazepino[1, 2-a]indole-12-sulfonate|Smiles: [Na+].COCCOCCOCCN(CC(C)(C)S)C1=CC(COC2=CC3N[C@H]([C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)S([O-])(=O)=O)=CC(COC2=CC3NC[C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)=C1|InChiKey: RNHTWDMUNIEDKX-ORJPSMTCSA-M|InChi: InChI=1S/C53H61N5O12S2.Na/c1-53(2,71)32-56(14-15-67-18-19-68-17-16-64-3)37-21-33(30-69-48-27-41-39(25-46(48)65-4)51(59)57-38(29-54-41)23-35-10-6-8-12-43(35)57)20-34(22-37)31-70-49-28-42-40(26-47(49)66-5)52(60)58-44-13-9-7-11-36(44)24-45(58)50(55-42)72(61,62)63;/h6-13,20-22,25-28,38,45,50,54-55,71H,14-19,23-24,29-32H2,1-5H3,(H,61,62,63);/q;+1/p-1/t38-,45-,50-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs). DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class.|Products are for research use only. Not for human use.|