Product Name :
Oclacitinib
Description:
Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 ‘s) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 ‘s > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 ‘s ranging from 36 to 249 nM.
CAS:
1208319-26-9
Molecular Weight:
337.44
Formula:
C15H23N5O2S
Chemical Name:
N-methyl-1-{4-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]cyclohexyl}methanesulfonamide
Smiles :
CNS(=O)(=O)CC1CCC(CC1)N(C)C1N=CN=C2NC=CC2=1
InChiKey:
HJWLJNBZVZDLAQ-UHFFFAOYSA-N
InChi :
InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Obinutuzumab} site|{Obinutuzumab} CD20|{Obinutuzumab} Technical Information|{Obinutuzumab} Data Sheet|{Obinutuzumab} custom synthesis|{Obinutuzumab} Autophagy}
Additional information:
Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy.{{Thiamine} MedChemExpress|{Thiamine} Endogenous Metabolite|{Thiamine} Purity & Documentation|{Thiamine} In stock|{Thiamine} supplier|{Thiamine} Autophagy} Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 ‘s) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 ‘s > 1000 nm).PMID:23865629 Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 ‘s ranging from 36 to 249 nM.|Product information|CAS Number: 1208319-26-9|Molecular Weight: 337.44|Formula: C15H23N5O2S|Chemical Name: N-methyl-1-{4-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]cyclohexyl}methanesulfonamide|Smiles: CNS(=O)(=O)CC1CCC(CC1)N(C)C1N=CN=C2NC=CC2=1|InChiKey: HJWLJNBZVZDLAQ-UHFFFAOYSA-N|InChi: InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|