Product Name :
Borussertib
Description:
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt.
CAS:
1800070-77-2
Molecular Weight:
596.68
Formula:
C36H32N6O3
Chemical Name:
N-[2-oxo-3-(1-{[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-5-yl]prop-2-enamide
Smiles :
C=CC(=O)NC1=CC2=C(C=C1)NC(=O)N2C1CCN(CC2C=CC(=CC=2)C2=NC3C=CNC(=O)C=3C=C2C2C=CC=CC=2)CC1
InChiKey:
HXBRBOYWXDLHDC-UHFFFAOYSA-N
InChi :
InChI=1S/C36H32N6O3/c1-2-33(43)38-26-12-13-31-32(20-26)42(36(45)40-31)27-15-18-41(19-16-27)22-23-8-10-25(11-9-23)34-28(24-6-4-3-5-7-24)21-29-30(39-34)14-17-37-35(29)44/h2-14,17,20-21,27H,1,15-16,18-19,22H2,(H,37,44)(H,38,43)(H,40,45)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Doravirine} medchemexpress|{Doravirine} Anti-infection|{Doravirine} Protocol|{Doravirine} In Vitro|{Doravirine} custom synthesis|{Doravirine} Autophagy}
Additional information:
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.{{Palladium (II)} MedChemExpress|{Palladium (II)} {Biochemical Assay Reagents}|{Palladium (II)} Purity & Documentation|{Palladium (II)} References|{Palladium (II)} custom synthesis|{Palladium (II)} Autophagy} 8 nM and a Ki of 2.PMID:24013184 2 nM for Aktwt.|Product information|CAS Number: 1800070-77-2|Molecular Weight: 596.68|Formula: C36H32N6O3|Chemical Name: N-[2-oxo-3-(1-{[4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-5-yl]prop-2-enamide|Smiles: C=CC(=O)NC1=CC2=C(C=C1)NC(=O)N2C1CCN(CC2C=CC(=CC=2)C2=NC3C=CNC(=O)C=3C=C2C2C=CC=CC=2)CC1|InChiKey: HXBRBOYWXDLHDC-UHFFFAOYSA-N|InChi: InChI=1S/C36H32N6O3/c1-2-33(43)38-26-12-13-31-32(20-26)42(36(45)40-31)27-15-18-41(19-16-27)22-23-8-10-25(11-9-23)34-28(24-6-4-3-5-7-24)21-29-30(39-34)14-17-37-35(29)44/h2-14,17,20-21,27H,1,15-16,18-19,22H2,(H,37,44)(H,38,43)(H,40,45)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (41.90 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Borussertib exhibits excellent cellular activity in the nanomolar range with superior profile against clinical candidate Akt inhibitors as well as the cytostatic drug doxorubicin. The EC50 values are 191±90 nM, 48±15 nM, 5±1 nM, 277±90 nM, 373±54 nM, 7770±641 nM in AN3CA (endometrium), T47D (breast), ZR-75-1 (breast), MCF-7 (breast), BT-474 (breast) and KU-19-19 (bladder) cell lines, respectively.|Products are for research use only. Not for human use.|