Product Name :
AZD1390
Description:
AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM in cell.
CAS:
2089288-03-7
Molecular Weight:
477.57
Formula:
C27H32FN5O2
Chemical Name:
7-fluoro-3-methyl-8-{6-[3-(piperidin-1-yl)propoxy]pyridin-3-yl}-1-(propan-2-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-2-one
Smiles :
CN1C(=O)N(C(C)C)C2C1=CN=C1C=C(F)C(=CC1=2)C1=CN=C(C=C1)OCCCN1CCCCC1
InChiKey:
VQSZIPCGAGVRRP-UHFFFAOYSA-N
InChi :
InChI=1S/C27H32FN5O2/c1-18(2)33-26-21-14-20(22(28)15-23(21)29-17-24(26)31(3)27(33)34)19-8-9-25(30-16-19)35-13-7-12-32-10-5-4-6-11-32/h8-9,14-18H,4-7,10-13H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM in cell.|Product information|CAS Number: 2089288-03-7|Molecular Weight: 477.57|Formula: C27H32FN5O2|Chemical Name: 7-fluoro-3-methyl-8-{6-[3-(piperidin-1-yl)propoxy]pyridin-3-yl}-1-(propan-2-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-2-one|Smiles: CN1C(=O)N(C(C)C)C2C1=CN=C1C=C(F)C(=CC1=2)C1=CN=C(C=C1)OCCCN1CCCCC1|InChiKey: VQSZIPCGAGVRRP-UHFFFAOYSA-N|InChi: InChI=1S/C27H32FN5O2/c1-18(2)33-26-21-14-20(22(28)15-23(21)29-17-24(26)31(3)27(33)34)19-8-9-25(30-16-19)35-13-7-12-32-10-5-4-6-11-32/h8-9,14-18H,4-7,10-13H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (52.{{Ibezapolstat} MedChemExpress|{Ibezapolstat} DNA/RNA Synthesis|{Ibezapolstat} Protocol|{Ibezapolstat} In Vitro|{Ibezapolstat} supplier|{Ibezapolstat} Epigenetics} 35 mM; Need ultrasonic and warming).{{DNQX} medchemexpress|{DNQX} Antagonist|{DNQX} Epigenetics|{DNQX} Technical Information|{DNQX} Description|{DNQX} custom synthesis} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:36717102 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Median survival of mice treated with AZD1390 and radiation are significantly longer than untreated control mice (p=0.001). No overt signs of treatment toxicity are observed with small animal radiation research platform (SARRP) contrary to wholehead irradiated mice that seem to develop mucositis and difficulties drinking and eating at doses >10 Gy in combination with AZD1390.|Products are for research use only. Not for human use.|