Product Name :
HTS01037
Description:
HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a Ki of 0.67 μM.
CAS:
682741-29-3
Molecular Weight:
337.37
Formula:
C14H11NO5S2
Chemical Name:
(2E)-3-{[5-(methoxycarbonyl)-[2,2′-bithiophen]-4-yl]carbamoyl}prop-2-enoic acid
Smiles :
COC(=O)C1SC(=CC=1NC(=O)/C=C/C(O)=O)C1=CC=CS1
InChiKey:
GJODSFZNKNHKML-SNAWJCMRSA-N
InChi :
InChI=1S/C14H11NO5S2/c1-20-14(19)13-8(15-11(16)4-5-12(17)18)7-10(22-13)9-3-2-6-21-9/h2-7H,1H3,(H,15,16)(H,17,18)/b5-4+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a Ki of 0.67 μM.|Product information|CAS Number: 682741-29-3|Molecular Weight: 337.37|Formula: C14H11NO5S2|Chemical Name: (2E)-3-{[5-(methoxycarbonyl)-[2,2′-bithiophen]-4-yl]carbamoyl}prop-2-enoic acid|Smiles: COC(=O)C1SC(=CC=1NC(=O)/C=C/C(O)=O)C1=CC=CS1|InChiKey: GJODSFZNKNHKML-SNAWJCMRSA-N|InChi: InChI=1S/C14H11NO5S2/c1-20-14(19)13-8(15-11(16)4-5-12(17)18)7-10(22-13)9-3-2-6-21-9/h2-7H,1H3,(H,15,16)(H,17,18)/b5-4+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 150 mg/mL (444.62 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|HTS01037 functions as a high affinity ligand of AFABP/aP2 with an apparent Ki of 0.67 μM. HTS01037 is somewhat selective for AFABP/aP2, but at higher concentrations is a pan-specific FABP inhibitor. HTS01037 inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.{{Elbasvir} site|{Elbasvir} HCV|{Elbasvir} Technical Information|{Elbasvir} Data Sheet|{Elbasvir} manufacturer|{Elbasvir} Autophagy} HTS01037 acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophage or CV-1 cells.{{Veratridine} MedChemExpress|{Veratridine} Sodium Channel|{Veratridine} Protocol|{Veratridine} Formula|{Veratridine} supplier|{Veratridine} Cancer} Treatment of microglial cells with HTS01037 increases expression of Ucp2 and arginase in the presence or absence of palmitic acid.PMID:24238415 Moreover, cells exposed to HTS01037 exhibits attenuated expression of inducible nitric oxide synthase (iNOS) compared to palmitic acid alone indicating reduced NFκB signaling. Treatment of macrophages with HTS01037results in a marked decrease in both basal and fatty acid-stimulated LTC4 secretion but no change in 5-HETE production or 5-lipoxygenase expression.|Products are for research use only. Not for human use.|