Product Name :
Lapatinib-d7 ditosylate
Description:
Lapatinib-d7 (GW572016-d7) ditosylate is the deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.
CAS:
1009307-24-7
Molecular Weight:
760.30
Formula:
C36H34ClFN4O7S2
Chemical Name:
4-methylbenzene-1-sulfonic acid; N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-[5-({[2-(²H₃)methanesulfonyl(1,1,2,2-²H₄)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
Smiles :
[2H]C([2H])([2H])S(=O)(=O)C([2H])([2H])C([2H])([2H])NCC1=CC=C(O1)C1=CC2=C(NC3=CC(Cl)=C(C=C3)OCC3C=C(F)C=CC=3)N=CN=C2C=C1.CC1C=CC(=CC=1)S(O)(=O)=O
InChiKey:
OZDXXJABMOYNGY-LXACFCGFSA-N
InChi :
InChI=1S/C29H26ClFN4O4S.C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2-5H,1H3,(H,8,9,10)/i1D3,11D2,12D2;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lapatinib-d7 (GW572016-d7) ditosylate is the deuterium labeled Lapatinib.{{Gentamicin} web|{Gentamicin} Bacterial|{Gentamicin} Technical Information|{Gentamicin} Data Sheet|{Gentamicin} supplier|{Gentamicin} Autophagy} Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.{{ICAM-5 Protein, Mouse (HEK293, His)} MedChemExpress|{ICAM-5 Protein, Mouse (HEK293, His)} Protocol|{ICAM-5 Protein, Mouse (HEK293, His)} In stock|{ICAM-5 Protein, Mouse (HEK293, His)} supplier|{ICAM-5 Protein, Mouse (HEK293, His)} Cancer} 2 and 9.PMID:32997552 8 nM, respectively.|Product information|CAS Number: 1009307-24-7|Molecular Weight: 760.30|Formula: C36H34ClFN4O7S2|Chemical Name: 4-methylbenzene-1-sulfonic acid; N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-[5-({[2-(²H₃)methanesulfonyl(1,1,2,2-²H₄)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine|Smiles: [2H]C([2H])([2H])S(=O)(=O)C([2H])([2H])C([2H])([2H])NCC1=CC=C(O1)C1=CC2=C(NC3=CC(Cl)=C(C=C3)OCC3C=C(F)C=CC=3)N=CN=C2C=C1.CC1C=CC(=CC=1)S(O)(=O)=O|InChiKey: OZDXXJABMOYNGY-LXACFCGFSA-N|InChi: InChI=1S/C29H26ClFN4O4S.C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2-5H,1H3,(H,8,9,10)/i1D3,11D2,12D2;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.|Products are for research use only. Not for human use.|