Product Name :
AP5
Description:
AP5 exhibits potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49±0.28 nM against the GPR40 receptor.
CAS:
1623194-37-5
Molecular Weight:
461.52
Formula:
C28H28FNO4
Chemical Name:
(2R,3S)-3-cyclopropyl-3-[(2R)-2-[2-fluoro-4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-1-benzopyran-7-yl]-2-methylpropanoic acid
Smiles :
C[C@H]([C@H](C1CC1)C1=CC=C2CC[C@@H](OC2=C1)C1=CC=C(C=C1F)C1=CC(=NC=C1)OC)C(O)=O
InChiKey:
ABSKJGYIWZMOAF-FLFAQTGJSA-N
InChi :
InChI=1S/C28H28FNO4/c1-16(28(31)32)27(18-4-5-18)21-6-3-17-8-10-24(34-25(17)14-21)22-9-7-19(13-23(22)29)20-11-12-30-26(15-20)33-2/h3,6-7,9,11-16,18,24,27H,4-5,8,10H2,1-2H3,(H,31,32)/t16-,24-,27-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AP5 exhibits potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49±0.28 nM against the GPR40 receptor.|Product information|CAS Number: 1623194-37-5|Molecular Weight: 461.52|Formula: C28H28FNO4|Chemical Name: (2R,3S)-3-cyclopropyl-3-[(2R)-2-[2-fluoro-4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-1-benzopyran-7-yl]-2-methylpropanoic acid|Smiles: C[C@H]([C@H](C1CC1)C1=CC=C2CC[C@@H](OC2=C1)C1=CC=C(C=C1F)C1=CC(=NC=C1)OC)C(O)=O|InChiKey: ABSKJGYIWZMOAF-FLFAQTGJSA-N|InChi: InChI=1S/C28H28FNO4/c1-16(28(31)32)27(18-4-5-18)21-6-3-17-8-10-24(34-25(17)14-21)22-9-7-19(13-23(22)29)20-11-12-30-26(15-20)33-2/h3,6-7,9,11-16,18,24,27H,4-5,8,10H2,1-2H3,(H,31,32)/t16-,24-,27-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Glimepiride} site|{Glimepiride} Amyloid-β|{Glimepiride} Protocol|{Glimepiride} References|{Glimepiride} custom synthesis|{Glimepiride} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Methazolamide} web|{Methazolamide} Metabolic Enzyme/Protease|{Methazolamide} Biological Activity|{Methazolamide} Data Sheet|{Methazolamide} custom synthesis|{Methazolamide} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33030111 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AP5 is a potent and selective GPR40 AgoPAM that demonstrates excellent in vivo efficacy. In the GK rat oral glucose tolerance test (oGTT), oral administration of AP5 1 h before an oral dextrose challenge shows that AP5 significantly reduces blood glucose levels compared to the vehicle. AP5 is determined to be more efficacious in this model, demonstrating maximally efficacious glucose lowering at a plasma concentration of 4.9 μM at 10 mg/kg.|Products are for research use only. Not for human use.|