Product Name :
MX69
Description:
MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
CAS:
1005264-47-0
Molecular Weight:
474.57
Formula:
C27H26N2O4S
Chemical Name:
4-8-[(3, 4-dimethylphenyl)sulfamoyl]-3H, 3aH, 4H, 5H, 9bH-cyclopenta[c]quinolin-4-ylbenzoic acid
Smiles :
CC1=CC=C(C=C1C)NS(=O)(=O)C1=CC2C3C=CCC3C(NC=2C=C1)C1C=CC(=CC=1)C(O)=O
InChiKey:
XCBONKHCCRJMNW-UHFFFAOYSA-N
InChi :
InChI=1S/C27H26N2O4S/c1-16-6-11-20(14-17(16)2)29-34(32,33)21-12-13-25-24(15-21)22-4-3-5-23(22)26(28-25)18-7-9-19(10-8-18)27(30)31/h3-4,6-15,22-23,26,28-29H,5H2,1-2H3,(H,30,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Pyrotinib EGFR
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.|Product information|CAS Number: 1005264-47-0|Molecular Weight: 474.57|Formula: C27H26N2O4S|Chemical Name: 4-8-[(3, 4-dimethylphenyl)sulfamoyl]-3H, 3aH, 4H, 5H, 9bH-cyclopenta[c]quinolin-4-ylbenzoic acid|Smiles: CC1=CC=C(C=C1C)NS(=O)(=O)C1=CC2C3C=CCC3C(NC=2C=C1)C1C=CC(=CC=1)C(O)=O|InChiKey: XCBONKHCCRJMNW-UHFFFAOYSA-N|InChi: InChI=1S/C27H26N2O4S/c1-16-6-11-20(14-17(16)2)29-34(32,33)21-12-13-25-24(15-21)22-4-3-5-23(22)26(28-25)18-7-9-19(10-8-18)27(30)31/h3-4,6-15,22-23,26,28-29H,5H2,1-2H3,(H,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (210.72 mM; Need ultrasonic) H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.Momelotinib JAK MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models.PMID:32898628 MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.|In Vivo:|MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo.|References:|Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636Products are for research use only. Not for human use.|