Product Name :
CYT387
Description:
Momelotinib, also known as CYT387, is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM). As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. Additional potential treatment indications for CYT387 include other myeloproliferative neoplasms, cancer (solid and liquid tumors) and inflammatory conditions.
CAS:
1056634-68-4
Molecular Weight:
414.46
Formula:
C23H22N6O2
Chemical Name:
N-(cyanomethyl)-4-(2-[4-(morpholin-4-yl)phenyl]aminopyrimidin-4-yl)benzamide
Smiles :
N#CCNC(=O)C1C=CC(=CC=1)C1=CC=NC(NC2C=CC(=CC=2)N2CCOCC2)=N1
InChiKey:
ZVHNDZWQTBEVRY-UHFFFAOYSA-N
InChi :
InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.Osimertinib Biological Activity
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Momelotinib, also known as CYT387, is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM). As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. Additional potential treatment indications for CYT387 include other myeloproliferative neoplasms, cancer (solid and liquid tumors) and inflammatory conditions.|Product information|CAS Number: 1056634-68-4|Molecular Weight: 414.46|Formula: C23H22N6O2|Chemical Name: N-(cyanomethyl)-4-(2-[4-(morpholin-4-yl)phenyl]aminopyrimidin-4-yl)benzamide|Smiles: N#CCNC(=O)C1C=CC(=CC=1)C1=CC=NC(NC2C=CC(=CC=2)N2CCOCC2)=N1|InChiKey: ZVHNDZWQTBEVRY-UHFFFAOYSA-N|InChi: InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Belinostat Technical Information |Shelf Life: ≥360 days if stored properly.PMID:31985991 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|