Ore; she has lectured at symposia sponsored by Allergan; she is PI or collaborator in clinical trials sponsored by Alder, electroCore, 3-Formyl rifamycin supplier Eli-Lilly and Teva. She has received grants in the European Commission, the Italian Ministry of Well being plus the Italian Ministry of UniversityReferences Scher AI, Buse DC, Fanning KM, Kelly AM, Franznick DA, Adams AM, Lipton RB. Comorbid discomfort and migraine chronicity: The Chronic Migraine Epidemiology and Outcomes Study. Neurology. 2017 Aug 1;89(five):461468. 1. Silberstein SD, Diamond S, Loder E, et al. Prevalence of migraine sufferers that are candidates for preventive therapy: benefits in the American migraine study (AMPP) study. Headache 2005; 45: 770771. Tassorelli C, Jensen R, Allena M, De Icco R, Katsarava Z, Miguel Lainez J, Leston JA, Fadic R, Spadafora S, Pagani M, Nappi G; COMOESTASThe Journal of Headache and Discomfort 2017, 18(Suppl 1):Web page 18 ofConsortium. The added value of an electronic monitoring and alerting technique within the management of medication-overuse headache: A controlled multicentre study. Cephalalgia. 2016 [Epub ahead of print]S52 Comorbidities in key headaches Antonio Carolei1,two, Cindy Tiseo1, Diana Degan1 1 Institute of Neurology, Division of Applied Clinical Sciences and Biotechnology, University of L’Aquila, by means of Vetoio, 67100 L’Aquila, Italy; 2 Division of Neurology and Stroke Unit, Avezzano Hospital, 67051, Avezzano, Italy Correspondence: Antonio Carolei ([email protected]) The Journal of Headache and Pain 2017, 18(Suppl 1):S52 According to the International Classification of Headache Disorders, 3rd edition (beta version) [1], principal headaches are classified as “migraine”, “tension-type headache”, “trigeminal autonomic cephalalgia”, and “other primary headache disorders”. To date, the majority of clinical research regarding primary headaches and their comorbidities are focused on migraine. Comorbidities of migraine might involve neurological and psychiatric situations, as mood issues (depression, mania, anxiety, panic attacks), epilepsy, critical tremor, stroke, and also the presence of white matter abnormalities [2]. Especially, a complicated and bidirectional relation among migraine and stroke has been described, like migraine as a danger element for cerebral ischemia, migraine caused by cerebral ischemia, migraine mimicking cerebral ischemia, migraine and cerebral ischemia sharing a popular bring about, and migraine linked with subclinical vascular brain lesions [2]. A recent meta-analysis pointed out that migraine is associated with improved ischemic stroke threat [3], and in accordance with a systematic assessment and meta-analysis [4] the danger of hemorrhagic stroke in migraineurs is improved with respect to non-migraineurs. Apart from, the risk of transient ischemic attack seems to be improved in migraineurs, while this situation has not been extensively investigated [5]. A recent systematic overview and meta-analysis also describes an enhanced danger of myocardial infarction and angina in migraineurs in comparison with nonmigraineurs [6]. Regarding the association among migraine and vascular risk elements (arterial hypertension, diabetes mellitus, dyslipidemia, obesity, alcohol consumption, family history of cardiovascular disease), a recent critique [7] showed no strong proof of an improved burden of traditional vascular threat factors in migraineurs, with the only exceptions of dyslipidemia and cigarette smoking, whilst a systematic review and meta-analysis relating to migraine and bod.