Renal extracellular matrix Bone Morphogenetic Protein 2 Proteins custom synthesis impact of a protein restricted diet regime was by means of the suppression of TGF-1 expression in antithymocyte serum-induced nephritis model.Bone morphogenetic protein-The TGF- superfamily includes additional than twenty types of bone morphogenetic proteins (BMPs), of which BMP-7 (also named as osteogenic protein-1) is closely involved in kidney development and disease. BMPs are differentially expressed throughout development. BMP-7 is initially expressed within the ureteric bud. Inside the development period, BMP-7 is also discovered inside the metanephric mesenchyme, early tubules, and within the podocytes of mature glomeruli. In the adult kidney, BMP-7 is expressed in glomerular podocytes, the thick ascending limb, the distal convoluted tubule, and also the collecting duct.51 As previously described, TGF-1 is regularly upregulated in models of experimenta.