da; 3University of Ottawa, Ottawa, Canada Background: Right ventricular (RV) dysfunction predicts worse outcomes in acute pulmonary embolism (PE). CT pulmonary angiography visualizes cardiac structures and might be a possible system for assessing RV without the need for transthoracic echocardiography. Aims: To conduct a systematic evaluation and meta-analysis to assessing the diagnostic accuracy of CT scan findings for detecting RV dysfunction in comparison to echocardiography. Strategies: We searched MEDLINE and EMBASE from inception to April 2020 for research comparing RV dysfunction on CT scan to echocardiography regular. Study good quality was assessed with the QUADAS-2 danger of bias tool. Meta-analysis was performed utilizing a bivariate mixed-effects regression framework. Results: All round, 26 research (three,508 sufferers) have been integrated. Indicators of RV dysfunction integrated reflux of contrast in to the inferior vena cava (IVC reflux;4 studies; 445 individuals), enhanced RV/ LV ratio (21 research; three,111 sufferers), and septal deviation (5 research; 459 individuals). Septal deviation had the highest specificity of 0.98 (95 CI = 0.90.00) a positive likelihood ratio of 13.six (95 CI = three.160.4), and also a constructive predictive value of 0.92 (0.87.98) for RV dysfunction (Table 1). For combinations of measurements, any of septal deviation, IVC reflux, or RV/LV 1.0 had 95 sensitivity and 88 specificity for RV dysfunction in one study (n = 59). General, most research had been judged to be at higher danger of bias by the QUADAS-2 tool (Figure 1). Conclusions: CT scanning is performed in most patients with suspected PE. RV dysfunction is usually detected by CT however the diagnostic accuracy when compared with echocardiography varies based on the distinct findings. The presence of septal bowing appears to become hugely distinct for RV dysfunction D2 Receptor Agonist Storage & Stability suggesting that echocardiography is not necessary when it really is present. While preliminary, ourABSTRACT863 of|findings suggest that findings on CT suggestive of RV dysfunction might negate the need for echocardiography access to which could be delayed or not readily available. Additional studies are warranted.PB1176|ISTH D2 Receptor Modulator Storage & Stability Definition of Pulmonary Embolism-related Death and Classification from the Cause of Death in Venous Thromboembolism Research: An Autopsy Study T. Tritschler1; S.P. Salvatore2; S.R. Kahn3,four; D. Garcia5; A. Delluc6; N. Kraaijpoel7; N. Langlois6; P. Girard8; G. Le GalDepartment of General Internal Medicine, Inselspital, Bern UniversityHospital, University of Bern, Bern, Switzerland; 2Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/ NewYork-Presbyterian Hospital, New York, Usa; 3Department of Medicine, McGill University, Montreal, Canada; 4Divisions of Internal Medicine and Clinical Epidemiology, Jewish General Hospital/ Lady Davis Institute, Montreal, Canada; 5Division of Hematology, Department of Medicine, University of Washington, Seattle, United states of america; 6Department of Medicine, Ottawa Hospital Study Institute, University of Ottawa, Ottawa, Canada; 7Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; 8Institut du Thorax Curie-Montsouris, Institut Mutualiste Montsouris, Paris, France Background: The ISTH’s SSC not too long ago proposed a definition of pulmonary embolism (PE)-related death, aiming to increase the reproducibility of adjudication of death events in venous thromboembolism studies. Aims: To evaluate the accuracy and interrater reliability of the ISTH definition of PE-relate