Product Name :
UCPH-101
Description:
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM.
CAS:
1118460-77-7
Molecular Weight:
422.48
Formula:
C27H22N2O3
Chemical Name:
2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
Smiles :
COC1C=CC(=CC=1)C1C(C#N)=C(N)OC2CC(CC(=O)C=21)C1=CC=CC2=CC=CC=C12
InChiKey:
YBMGNDPBARCLFT-UHFFFAOYSA-N
InChi :
InChI=1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Toceranib} MedChemExpress|{Toceranib} Protein Tyrosine Kinase/RTK|{Toceranib} Purity & Documentation|{Toceranib} Data Sheet|{Toceranib} custom synthesis|{Toceranib} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Olitigaltin} MedChemExpress|{Olitigaltin} Galectin|{Olitigaltin} Purity & Documentation|{Olitigaltin} In Vitro|{Olitigaltin} manufacturer|{Olitigaltin} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM.|Product information|CAS Number: 1118460-77-7|Molecular Weight: 422.48|Formula: C27H22N2O3|Chemical Name: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile|Smiles: COC1C=CC(=CC=1)C1C(C#N)=C(N)OC2CC(CC(=O)C=21)C1=CC=CC2=CC=CC=C12|InChiKey: YBMGNDPBARCLFT-UHFFFAOYSA-N|InChi: InChI=1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (236.PMID:23672196 70 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048).|Products are for research use only. Not for human use.|