Product Name :
AHN 1-055 hydrochloride
Description:
AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse.
CAS:
202646-03-5
Molecular Weight:
379.87
Formula:
C21H24ClF2NO
Chemical Name:
3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride
Smiles :
Cl.CN1C2CC(CC1CC2)OC(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1
InChiKey:
YOORVSGDAHWVMC-UHFFFAOYSA-N
InChi :
InChI=1S/C21H23F2NO.ClH/c1-24-18-10-11-19(24)13-20(12-18)25-21(14-2-6-16(22)7-3-14)15-4-8-17(23)9-5-15;/h2-9,18-21H,10-13H2,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse.|Product information|CAS Number: 202646-03-5|Molecular Weight: 379.87|Formula: C21H24ClF2NO|Chemical Name: 3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride|Smiles: Cl.CN1C2CC(CC1CC2)OC(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1|InChiKey: YOORVSGDAHWVMC-UHFFFAOYSA-N|InChi: InChI=1S/C21H23F2NO.ClH/c1-24-18-10-11-19(24)13-20(12-18)25-21(14-2-6-16(22)7-3-14)15-4-8-17(23)9-5-15;/h2-9,18-21H,10-13H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (329.06 mM; Need ultrasonic). H2O : 33.33 mg/mL (87.74 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Natamycin} medchemexpress|{Natamycin} Anti-infection|{Natamycin} Biological Activity|{Natamycin} In Vitro|{Natamycin} manufacturer|{Natamycin} Cancer} |Shelf Life: ≥12 months if stored properly.{{Mitapivat} site|{Mitapivat} Metabolic Enzyme/Protease|{Mitapivat} Technical Information|{Mitapivat} Formula|{Mitapivat} custom synthesis|{Mitapivat} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23439434 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|AHN 1-055 (5 mg/kg; i.v.) inhibits the uptaking of brain dopamine with an IC50 of 311.8 ng/ml in vivo. AHN 1-055 (10 mg/kg; i.v.) exhibits Cmax of 1.48 mg/L and terminal elimination half-lives of 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution.|Products are for research use only. Not for human use.|