Product Name :
SPOP-IN-6b
Description:
SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor extracted from patent CN 107141287, SPOP-B-88.
CAS:
2136270-20-5
Molecular Weight:
500.59
Formula:
C28H32N6O3
Chemical Name:
6-imino-11-methyl-N-[3-(morpholin-4-yl)propyl]-2-oxo-7-(2-phenylethyl)-1,7,9-triazatricyclo[8.4.0.0³,⁸]tetradeca-3(8),4,9,11,13-pentaene-5-carboxamide
Smiles :
CC1=CC=CN2C1=NC1=C(C=C(C(=N)N1CCC1C=CC=CC=1)C(=O)NCCCN1CCOCC1)C2=O
InChiKey:
RYTGHNMOSCSWJT-UHFFFAOYSA-N
InChi :
InChI=1S/C28H32N6O3/c1-20-7-5-13-34-25(20)31-26-23(28(34)36)19-22(24(29)33(26)14-10-21-8-3-2-4-9-21)27(35)30-11-6-12-32-15-17-37-18-16-32/h2-5,7-9,13,19,29H,6,10-12,14-18H2,1H3,(H,30,35)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Methyl cellulose} medchemexpress|{Methyl cellulose} {Biochemical Assay Reagents}|{Methyl cellulose} Biological Activity|{Methyl cellulose} In stock|{Methyl cellulose} custom synthesis|{Methyl cellulose} Epigenetics}
Additional information:
SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor extracted from patent CN 107141287, SPOP-B-88.{{Pravastatin} site|{Pravastatin} Ferroptosis|{Pravastatin} Technical Information|{Pravastatin} Description|{Pravastatin} supplier|{Pravastatin} Epigenetics} |Product information|CAS Number: 2136270-20-5|Molecular Weight: 500.59|Formula: C28H32N6O3|Chemical Name: 6-imino-11-methyl-N-[3-(morpholin-4-yl)propyl]-2-oxo-7-(2-phenylethyl)-1,7,9-triazatricyclo[8.4.0.0³,⁸]tetradeca-3(8),4,9,11,13-pentaene-5-carboxamide|Smiles: CC1=CC=CN2C1=NC1=C(C=C(C(=N)N1CCC1C=CC=CC=1)C(=O)NCCCN1CCOCC1)C2=O|InChiKey: RYTGHNMOSCSWJT-UHFFFAOYSA-N|InChi: InChI=1S/C28H32N6O3/c1-20-7-5-13-34-25(20)31-26-23(28(34)36)19-22(24(29)33(26)14-10-21-8-3-2-4-9-21)27(35)30-11-6-12-32-15-17-37-18-16-32/h2-5,7-9,13,19,29H,6,10-12,14-18H2,1H3,(H,30,35)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 10 mg/mL (19.PMID:25429455 98 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SPOP-IN-6b a SPOP inhibitor with an IC50 of 3.58 μM in cell assay. SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content. SPOP-IN-6b suppresses intracellular SPOP acted on substrate PTEN ubiquitination.|In Vivo:|SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP.|Products are for research use only. Not for human use.|