Product Name :
GAK inhibitor 49
Description:
GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2.
CAS:
319492-82-5
Molecular Weight:
370.40
Formula:
C20H22N2O5
Chemical Name:
6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine
Smiles :
COC1=CC2=C(C=CN=C2C=C1OC)NC1C=C(OC)C(OC)=C(C=1)OC
InChiKey:
VYPGLYMWNDRFGZ-UHFFFAOYSA-N
InChi :
InChI=1S/C20H22N2O5/c1-23-16-10-13-14(6-7-21-15(13)11-17(16)24-2)22-12-8-18(25-3)20(27-5)19(9-12)26-4/h6-11H,1-5H3,(H,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ropeginterferon alfa-2b} web|{Ropeginterferon alfa-2b} Apoptosis|{Ropeginterferon alfa-2b} Purity & Documentation|{Ropeginterferon alfa-2b} References|{Ropeginterferon alfa-2b} supplier|{Ropeginterferon alfa-2b} Autophagy}
Shelf Life:
≥12 months if stored properly.{{BI 1015550} medchemexpress|{BI 1015550} Phosphodiesterase (PDE)|{BI 1015550} Technical Information|{BI 1015550} Purity|{BI 1015550} manufacturer|{BI 1015550} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24423657
Additional information:
GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2.|Product information|CAS Number: 319492-82-5|Molecular Weight: 370.40|Formula: C20H22N2O5|Chemical Name: 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine|Smiles: COC1=CC2=C(C=CN=C2C=C1OC)NC1C=C(OC)C(OC)=C(C=1)OC|InChiKey: VYPGLYMWNDRFGZ-UHFFFAOYSA-N|InChi: InChI=1S/C20H22N2O5/c1-23-16-10-13-14(6-7-21-15(13)11-17(16)24-2)22-12-8-18(25-3)20(27-5)19(9-12)26-4/h6-11H,1-5H3,(H,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (134.99 mM; ultrasonic and warming and heat to 80°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GAK inhibitor 49 (compound 49) shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC50s of 28, 63 and >100 μM, respectively.|Products are for research use only. Not for human use.|