Product Name :
9-Decyn-1-ol
Description:
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.
CAS:
17643-36-6
Molecular Weight:
154.25
Formula:
C10H18O
Chemical Name:
dec-9-yn-1-ol
Smiles :
C#CCCCCCCCCO
InChiKey:
KOAOUMQUUZNRLL-UHFFFAOYSA-N
InChi :
InChI=1S/C10H18O/c1-2-3-4-5-6-7-8-9-10-11/h1,11H,3-10H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SQ109} web|{SQ109} Antibiotic|{SQ109} Protocol|{SQ109} In Vitro|{SQ109} custom synthesis|{SQ109} Cancer}
Shelf Life:
≥12 months if stored properly.{{C6 Ceramide} web|{C6 Ceramide} Apoptosis|{C6 Ceramide} Protocol|{C6 Ceramide} Formula|{C6 Ceramide} custom synthesis|{C6 Ceramide} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24633055
Additional information:
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.|Product information|CAS Number: 17643-36-6|Molecular Weight: 154.25|Formula: C10H18O|Chemical Name: dec-9-yn-1-ol|Smiles: C#CCCCCCCCCO|InChiKey: KOAOUMQUUZNRLL-UHFFFAOYSA-N|InChi: InChI=1S/C10H18O/c1-2-3-4-5-6-7-8-9-10-11/h1,11H,3-10H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker.|Products are for research use only. Not for human use.|