Product Name :
Azido-PEG2-C2-amine
Description:
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
CAS:
166388-57-4
Molecular Weight:
174.20
Formula:
C6H14N4O2
Chemical Name:
1-(2-aminoethoxy)-2-(2-azidoethoxy)ethane
Smiles :
[N-]=[N+]=NCCOCCOCCN
InChiKey:
ZHWGWSYNZIZTFL-UHFFFAOYSA-N
InChi :
InChI=1S/C6H14N4O2/c7-1-3-11-5-6-12-4-2-9-10-8/h1-7H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).|Product information|CAS Number: 166388-57-4|Molecular Weight: 174.20|Formula: C6H14N4O2|Chemical Name: 1-(2-aminoethoxy)-2-(2-azidoethoxy)ethane|Smiles: [N-]=[N+]=NCCOCCOCCN|InChiKey: ZHWGWSYNZIZTFL-UHFFFAOYSA-N|InChi: InChI=1S/C6H14N4O2/c7-1-3-11-5-6-12-4-2-9-10-8/h1-7H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tobramycin} MedChemExpress|{Tobramycin} Anti-infection|{Tobramycin} Protocol|{Tobramycin} References|{Tobramycin} custom synthesis|{Tobramycin} Cancer} |Shelf Life: ≥12 months if stored properly.{{SCF Protein, Human} MedChemExpress|{SCF Protein, Human} Biological Activity|{SCF Protein, Human} References|{SCF Protein, Human} supplier|{SCF Protein, Human} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23290930 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|Products are for research use only. Not for human use.|