Product Name :
ARS-1323-alkyne
Description:
ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
CAS:
2436544-27-1
Molecular Weight:
569.00
Formula:
C28H27ClF2N6O3
Chemical Name:
3-{[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[4-(prop-2-enoyl)piperazin-1-yl]quinazolin-2-yl]amino}-N-methyl-N-(prop-2-yn-1-yl)propanamide
Smiles :
CN(CC#C)C(=O)CCNC1=NC2=C(C=C(Cl)C(C3=C(O)C=CC=C3F)=C2F)C(=N1)N1CCN(CC1)C(=O)C=C
InChiKey:
FCCFZQSNDSLLMI-UHFFFAOYSA-N
InChi :
InChI=1S/C28H27ClF2N6O3/c1-4-11-35(3)22(40)9-10-32-28-33-26-17(27(34-28)37-14-12-36(13-15-37)21(39)5-2)16-18(29)23(25(26)31)24-19(30)7-6-8-20(24)38/h1,5-8,16,38H,2,9-15H2,3H3,(H,32,33,34)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.|Product information|CAS Number: 2436544-27-1|Molecular Weight: 569.00|Formula: C28H27ClF2N6O3|Chemical Name: 3-{[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[4-(prop-2-enoyl)piperazin-1-yl]quinazolin-2-yl]amino}-N-methyl-N-(prop-2-yn-1-yl)propanamide|Smiles: CN(CC#C)C(=O)CCNC1=NC2=C(C=C(Cl)C(C3=C(O)C=CC=C3F)=C2F)C(=N1)N1CCN(CC1)C(=O)C=C|InChiKey: FCCFZQSNDSLLMI-UHFFFAOYSA-N|InChi: InChI=1S/C28H27ClF2N6O3/c1-4-11-35(3)22(40)9-10-32-28-33-26-17(27(34-28)37-14-12-36(13-15-37)21(39)5-2)16-18(29)23(25(26)31)24-19(30)7-6-8-20(24)38/h1,5-8,16,38H,2,9-15H2,3H3,(H,32,33,34)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 35.{{Agarose} web|{Agarose} Purity & Documentation|{Agarose} Formula|{Agarose} custom synthesis|{Agarose} Autophagy} 71 mg/mL (62.{{Anti-Mouse IFNAR1 Antibody} site|{Anti-Mouse IFNAR1 Antibody} Immunology/Inflammation|{Anti-Mouse IFNAR1 Antibody} Biological Activity|{Anti-Mouse IFNAR1 Antibody} In stock|{Anti-Mouse IFNAR1 Antibody} custom synthesis|{Anti-Mouse IFNAR1 Antibody} Epigenetics} 76 mM; Need ultrasonic).PMID:24834360 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|