Product Name :
AZD9898
Description:
AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma.
CAS:
2042347-69-1
Molecular Weight:
457.83
Formula:
C20H19ClF3N3O4
Chemical Name:
(1S,2S)-2-{5-[(5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazine-2-carbonyl}cyclopropane-1-carboxylic acid
Smiles :
COC1=NC(=CN=C1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC(C)(C)F)C1=CC(Cl)=C(F)C=C1F
InChiKey:
RVMWIVNHZMXEHS-UWVGGRQHSA-N
InChi :
InChI=1S/C20H19ClF3N3O4/c1-20(2,24)8-27(14-5-11(21)12(22)6-13(14)23)15-7-25-16(18(26-15)31-3)17(28)9-4-10(9)19(29)30/h5-7,9-10H,4,8H2,1-3H3,(H,29,30)/t9-,10-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Protease Inhibitor Cocktail, Bacteria} medchemexpress|{Protease Inhibitor Cocktail, Bacteria} Activator|{Protease Inhibitor Cocktail, Bacteria} Biological Activity|{Protease Inhibitor Cocktail, Bacteria} In stock|{Protease Inhibitor Cocktail, Bacteria} custom synthesis}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.{{TBB} medchemexpress|{TBB} Cell Cycle/DNA Damage|{TBB} Technical Information|{TBB} Data Sheet|{TBB} manufacturer|{TBB} Epigenetic Reader Domain} 28 nM.PMID:32554526 AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma.|Product information|CAS Number: 2042347-69-1|Molecular Weight: 457.83|Formula: C20H19ClF3N3O4|Chemical Name: (1S,2S)-2-{5-[(5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazine-2-carbonyl}cyclopropane-1-carboxylic acid|Smiles: COC1=NC(=CN=C1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC(C)(C)F)C1=CC(Cl)=C(F)C=C1F|InChiKey: RVMWIVNHZMXEHS-UWVGGRQHSA-N|InChi: InChI=1S/C20H19ClF3N3O4/c1-20(2,24)8-27(14-5-11(21)12(22)6-13(14)23)15-7-25-16(18(26-15)31-3)17(28)9-4-10(9)19(29)30/h5-7,9-10H,4,8H2,1-3H3,(H,29,30)/t9-,10-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised.|Products are for research use only. Not for human use.|