Product Name :
Tau-381 (1N3R variant) (human), (recombinant)
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Molecular Weight:
39.7 kDa
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Description:
The tau proteins are major neuronal microtubule-associated proteins that function in the stabilization of microtubules and accumulate in various abnormal filaments including neurofibrillary tangles, neuropil threads and amyloid plaques in the pathology of Alzheimer’s disease.425399-05-9 Biological Activity Six tau isoforms are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.1374663-29-2 Purity 8 to 45.9 kDa). The six isoforms differ from one another in having three or four microtubule binding repeats (R) and two, one or zero amino terminal inserts (N). While the fetal brain contains a single isoform of tau (Tau-352), the adult brain has several isoforms.
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Additional Information :
| Application Notes This protein is purified without any acid treatment and is suitable for promoting microtubule assembly, and for hyperphosphorylation-induced self-assembly into filaments.PMID:25905215 | Formulation Lyophilized from 50mM MES, pH 6.8, 100mM NaCl and 0.5mM EGTA. | MW 39.7 kDa | Source Produced in E. coli. | UniProt ID P10636