To evaluate the position of p130Cas in EGFR activation and stabilization at the cell area induced by mobile adhesion, we transfected A431 cells with non-focusing on or p130Cas-distinct siRNA and examined the outcome of knocking down p130Cas

Mobile adhesion to fibronectin (FN) induces slight enhance of EGFR and formation of macromolecular complexes comprised of EGFR, integrin, p130Cas and Src kinase. Upon intricate formation, particular EGFR tyrosine residues,…