Replication-faulty mutants of other huge DNA viruses, such as herpes simplex virus [34,35,36,37], adenovirus [38], and vaccinia virus [39], have been developed for use as vaccine vectors, but this approach has not but been possible with MVA
Modified Vaccinia virus Ankara (MVA), an attenuated strain of vaccinia virus that was at first produced as a smallpox vaccine, was acquired next comprehensive serial passage on principal rooster embryo…